![]() It showed that incorporation of active monitoring led to targeted changes with a higher frequency of medication titration and reduced HF hospitalizations. #IVCD HEART RHYTHM TRIAL#The CHAMPION (CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in Class III HF) trial was a randomized, controlled, single-blind trial that evaluated this device (active PA pressure-guided monitoring group) with standard care versus standard care with clinical assessment in 550 NYHA class III HF patients. The information can be submitted electronically to patients' healthcare providers. 44 Implantable Pulmonary Artery Pressure SensorĬardioMEMS is currently the only FDA-approved miniaturized, wireless monitoring sensor that is implanted in the pulmonary artery to measure PA pressure directly. 43 A survival benefit is seen in those patients with HF and CKD who are responsive to cardiac resynchronization therapy (CRT), as well as preservation and improvement of renal function in some cases. Intraventricular conduction delay can be seen in up to 20% to 30% of those with symptomatic HF resulting in dyssynchrony and reduction in pump performance. Thakar, in Critical Care Nephrology (Third Edition), 2019 Over the Horizon Cardiac Resynchronization Therapy This is highlighted by the observation that simultaneous BiV pacing yields evidence of ventricular activation fusion, which is necessary for reverse volumetric remodeling, in only about 55% of cases. ![]() The ability to orchestrate ventricular chamber timing should theoretically provide additional leverage for overcoming functional and physiologic conduction barriers, to obtain maximum evidence of ventricular activation wavefront fusion. 6Įquivalent conduction times between widely spaced RV and LV stimulation sites does not guarantee that simultaneous BiV pacing will generate global ventricular activation wavefront fusion.Īgainst this background, a role of timed (sequential) ventricular stimulation exists. Selection of LV pacing sites based on interventricular timing recorded by local EGMs (RV, LV) may be misleading because simultaneous activation timing at widely spaced RV and LV sites may occur in LBBB and does not indicate absence of mechanical delay. Resynchronization of the most delayed LV region may be irrelevant if there is a large intervening zone of scar. 3Īny pacing site may induce or worsen conduction block unpredictably and degrade or abolish ventricular activation wavefront fusion. Stimulation from these sites can effectively correct LV conduction delay and probably explains why some patients improve with non–LV posterior wall stimulation. Other unpredictable sites (anterior wall, apex) may be latest activated in some patients because of the effects of conduction blocks on wavefront propagation. ![]() ![]() The LV posterior wall adjacent to the mitral annulus is almost always the latest electrically activated (most delayed) site during LBBB conduction and should be targeted for LV pacing. Based on current limited understanding of the problem, the following conclusions can be made: 1 Ventricular conduction blocks present diverse and unpredictable challenges to generating ventricular activation wavefront fusion during CRT. ![]()
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FREE MASTERING PLUGINS FOR GARAGEBAND HOW TOIf you're interested in becoming a great at mastering you can next learn how to put together a mastering signal chain. In this article, we will explore the best mastering plugins for your tracks so you can capture the full essence and energy of your music. ![]() ![]() Mastering is the element that separates a track that sounds like it was recorded using an iPhone in a garage from a track that sounds like it was recorded in Abbey Road Studios. Learn How to Master Your Music, For Free! You can create the best song in the world but if it isn’t mastered correctly, it will come out wimpy and underwhelming. Its purpose is to capture the essence of your music. Mastering is a key element to any successful recording. Note : This article may contain affiliate links, meaning I would receive a commission - at no cost to you - for any products you purchase. Do you feel like your songs are lacking that special something you hear in professional recordings? Are you struggling to make your songs loud and punchy? Or do you feel like they're just missing a little extra polish? Then you need to up your mastering game. ![]() ![]() ![]() ![]() Not to mention that such an expansion theme would be something we've never seen before. Considering that there are fans out there who would like an underground-based expansion, an entire expansion revolving around an underground continent could be quite appealing to a segment of the fanbase. However, #1 is interesting as well, because the Undermine was originally conceived as a continent in WoW beta, which could indicate that the Undermine could be a continent in a future expansion. Kezan is scheduled to be a dungeon in the next expansion, so I found #2 particularly interesting. Now here's some interesting facts about Undermine as it involves WoW:ġ.Note that the Undermine was already in the early World of Warcraft Betas not as a city on a island, but as a continent south of Kalimdor, but there was only water there and nothing else.Ģ.At BlizzCon 2010, it was stated that the goblins will go back to reclaim Kezan, and the rest of Kezan and the Undermine will be accessible to players at an unknown point in the future. Trolls originally enslaved the goblins and forced them to mine kaja'mite ore from the bowels of Mount Kajaro. As a result, Undermine is a busy place, as the goblin fortress city goes about its business. The princes each control their own private armies and trade fleets. Undermine is home to the fabled goblin trade princes, who hide from Alliance and Horde authorities on Kalimdor. Making their home in the Undermine are the goblins, who are native to the island. 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Having the ability to teach includes presenting your own experience and education in an easily understood way. It can be important for venture capitalists to teach coworkers and startup companies further knowledge of investing and business. Venture Capital: What's the Difference? Teaching Determination also helps current venture capitalists seek more investment opportunities and thoroughly analyze business proposals to help them in their investment accuracy. Related: Guide To Understanding Venture Capital Determinationĭetermination is important for aspiring venture capitalists because it can show potential employers their passion for a career in the field and the effort they will give to the job if offered a position. When venture capital companies are looking for new employees to join their staff, they might look for someone who can act with precision and know when a startup business is a good idea to invest in or not. Investing a precise amount of money into a startup and receiving a large return on investment can be very beneficial to venture capitalists' careers. Understanding what company to invest in and how much money to give them is important for a venture capitalist. Here are some important skills that you can expect most venture capitalists to have: Investment accuracy Related: What Does a Venture Capitalist Do? Skills for venture capital careers Venture capitalists typically work in venture capital companies and firms, and their career paths generally progress through these positions: These professionals can also negotiate deals for startup companies and investors and help companies grow. ![]() Venture capital careers are positions in which individuals work to raise funds and invest in startup businesses. In this article, we discuss what venture capital careers are and the skills, education and experience necessary for raising funds for a startup business. ![]() Learning more about this career path can help you obtain the appropriate qualifications and have successful ventures. These entrepreneurs raise funds for startup businesses and ensure their success via management skills. If you're looking for a career in finance and investing where you can make influential decisions and help companies grow, consider a career in venture capital. Venture capitalist salary how to#Principals are on a “partner track,” depending on the returns they can generate from the deals they make. Partners are primarily focused on identifying areas or specific businesses to invest in, approving deals whether they be investments or exits, occasionally sitting on the board of portfolio companies, and generally representing the firm.Related: Becoming a Private Equity AssociateĪre you interested in a career in Private Equity but not sure how to start preparing for it? We have you covered!.They are also in charge of identifying investment opportunities for the firm to invest in and negotiating terms for both acquisition and exit. A principal is a mid-level professional, usually serving on the board of portfolio companies and in charge of making sure they’re operating without any big hiccups.Although they do not make key decisions, associates may introduce promising companies to the firm's upper management. They tend to more analytical work, analyzing business models, industry trends, and sectors, while also working with companies in a firm’s portfolio. Associates usually come into VC firms with experience in either business consulting or finance, and sometimes a degree in business. ![]() ![]() ![]()
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![]() Scavenger World: Most of the construction resources you find around the settlement are the ruins of older buildings that your colonists gradually break down so other things can be built from them.Thankfully there are no more than a few of them in any one map. They spit damaging compounds, have a huge health pool, and generally require several specialists to take down. Like the namesake, they are burrowers and can mostly be found in sandy areas, but rather than "swim" they seem to be ambush predators, digging underground bivouacs to lie in and conserve energy while waiting for prey to draw near. Sandworm: Technically they're giant mutant centipedes, but still referred to as "sandworms".In the early game, many of these will be scavenged from the environment around the colony as well as ruins further afield, but options to produce or trade for those resources open up as the colony develops. Various medicines for treating ailments, fiber for clothmaking, cloths for wearing, tools for doing work, and all the variety of more advanced materials need to be sourced. In addition to being drunk, many buildings require water, and more advanced buildings require electricity as well. Colonists require sufficient food, and not only in totals, they require a variety of food and food that's well prepared to stay fully healthy. Buildings need construction material stockpiled to be built as well as to be repaired when it inevitably is damaged or worn down. Resources Management Gameplay: A huge part of the gameplay.The "Alternative Proteins" advancement in the Tech Tree allows you to build climate-controlled bug farms for this purpose. Reduced to Ratburgers: Your colonists don't seem to mind, but your food sources can include scavenging for cockroaches, crickets, and various worms.Random Event: Every few days or so, your colony will have an event of some kind that will require you to make a choice.Non-Entity General: You aren't any colonist in particular, although many events portray you interacting directly with the other colonists.Nominal Importance: Specialists have unique portraits, names, and a short biography displayed when they arrive.Nobody Poops: Averted after the Tainted Earth update: Outhouses are the first step for maintaining the hygiene of your colonists, but accrue pollution quickly.Of course, you still have to dig these coins up among the ruins. Other colonies, mercenary specialists, and even bandits will accept silver coins as currency, despite that there is no government to back them. Money Is Not Power: Conspicuously averted, given the After the End setting.Depending on how strong your gate is and the quality of the people manning it, the bandits can either be driven back completely, moderately crippled when they begin their assault in earnest, or barely even affected. Hold the Line: when your base is assaulted by most bandits, they will first attempt to breach the front gate. ![]() Specialists are also the only ones who can leave the colony to interact with the world map. While you can turn ordinary colonists into defenders with your guard posts, your specialists will always be far more adept at fighting.
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Intelligence officials worry that SolarWinds might presage something on that scale. Even this much later, it is considered the most destructive and costly cyberattack in history. They planted ransomware that paralyzed multinational companies and permanently locked people around the world out of tens of thousands of computers. It, too, began with tainted software, but in that case the hackers were bent on destruction. When cybersecurity experts talk about harm, they're thinking about something like what happened in 2017, when the Russian military launched a ransomware attack known as NotPetya. ![]() This had the potential to affect thousands of customers this had the potential to do a great deal of harm." "It's really your worst nightmare," Tim Brown, vice president of security at SolarWinds, said recently. By its very nature, it touches everything - which is why hacking it was genius. Programs like Orion allow information technology departments to look on one screen and check their whole network: servers or firewalls, or that printer on the fifth floor that keeps going offline. HIGH SCHOOL STORY HACK SOFTWARENetwork monitoring software is a key part of the backroom operations we never see. And given the history of Russia's malicious activity in cyberspace and their reckless behavior in cyberspace, that was a key concern." "And a defender cannot move at that speed. "The speed with which an actor can move from espionage to degrading or disrupting a network is at the blink of an eye," one senior administration said during a background briefing from the White House on Thursday. The concern is that the same access that gives the Russians the ability to steal data could also allow them to alter or destroy it. The hackers also found their way, rather embarrassingly, into the Cybersecurity and Infrastructure Security Agency, or CISA - the office at the Department of Homeland Security whose job it is to protect federal computer networks from cyberattacks. HIGH SCHOOL STORY HACK FULLHe was hired shortly before the breach was discovered and stepped into the job just as the full extent of the hack became clear.ĭemetrius Freeman/Pool/AFP via Getty Images SolarWinds CEO and President Sudhakar Ramakrishna inherited the attack. The second was that their compromised networks needed to be connected to the Internet, so the hackers could communicate with their servers. HIGH SCHOOL STORY HACK UPDATEIts victims had to download the tainted update and then actually deploy it. NPR's months-long examination of that landmark attack - based on interviews with dozens of players from company officials to victims to cyber forensics experts who investigated, and intelligence officials who are in the process of calibrating the Biden administration's response - reveals a hack unlike any other, launched by a sophisticated adversary who took aim at a soft underbelly of digital life: the routine software update.īy design, the hack appeared to work only under very specific circumstances. On Thursday, the Biden administration announced a roster of tough sanctions against Russia as part of what it characterized as the "seen and unseen" response to the SolarWinds breach. We are still conducting the investigation." "If you then take 18,000 and start sifting through it, the actual number of impacted customers is far less. HIGH SCHOOL STORY HACK CODE"Eighteen thousand was our best estimate of who may have downloaded the code between March and June of 2020," Sudhakar Ramakrishna, SolarWinds president and CEO, told NPR. Hackers believed to be directed by the Russian intelligence service, the SVR, used that routine software update to slip malicious code into Orion's software and then used it as a vehicle for a massive cyberattack against America. The routine update, it turns out, is no longer so routine. ![]() HIGH SCHOOL STORY HACK PASSWORDCustomers simply had to log into the company's software development website, type a password and then wait for the update to land seamlessly onto their servers. It was supposed to provide the regular fare - bug fixes, performance enhancements - to the company's popular network management system, a software program called Orion that keeps a watchful eye on all the various components in a company's network. Last spring, a Texas-based company called SolarWinds made one such software update available to its customers. The next morning, rather like the shoemaker and the elves, our software is magically transformed. A pop-up window announces its arrival and all that is required of us is to plug everything in before bed. The routine software update may be one of the most familiar and least understood parts of our digital lives. "This release includes bug fixes, increased stability and performance improvements." An NPR investigation into the SolarWinds attack reveals a hack unlike any other, launched by a sophisticated adversary intent on exploiting the soft underbelly of our digital lives. ![]() ![]() ![]() the 16.37-carat Amarillo Starlight the 15.33-carat Star of Arkansas and the 8.52-carat Esperanza. Notable diamonds found at the Crater include the 40.23-carat Uncle Sam, the largest diamond ever unearthed in the U.S. ![]() More than 33,100 diamonds have been found by park visitors since the Crater of Diamonds became an Arkansas state park in 1972. Park staff provide complimentary identification of rocks and minerals found at the park, as well as diamond mining demonstrations and other interpretive programs. I highly recommend this shop for anyone who wants related items. In fact, they have quite a collection including citrine, quartz, amethyst, and more. I visited their online store and was happy to see the rosary I wanted. Amethyst, garnet, jasper, agate, quartz, and other rocks and minerals naturally occur here. I decided to buy some rosary beads and one of my friends suggested I try Shiv Rattan Kendra. Diamonds come in all colors of the rainbow: the three colors found here at the park are white, brown, and yellow. #BUY AMETHYST GEMSTONE ONLINE HOW TO#At the Diamond Discovery Center, you can learn more about rocks and minerals found at the park and how to search for diamonds using various techniques. At the park's visitor center, you can view real, uncut diamonds and interact with exhibits illustrating the area's unique history and geology. You may bring your own mining equipment to search with (no battery-operated or motor-driven mining tools allowed), or rent tools from the park.Your diamond search begins here, where you can prepare for your visit by learning about diamonds and how to search for them. Visitors to the park search a 37-acre field, the eroded surface of a volcanic crater, for a variety of rocks, minerals, and gemstones – and any rock or mineral you find is yours to keep. ![]() One of the only places in the world where the public can search for real diamonds in their original volcanic source, Crater of Diamonds is a one-of-a-kind experience that brings people from all over the world to Murfreesboro, Arkansas. ![]() ![]() In Australia, the CD was released in two formats, although one version (the international single) had an extremely limited run and was not widely available. The instrumental of this version was also used during many television performances of "Maneater". A lot of people say it sounds like Peaches, because of the delivery, the spooky vocals." įurtado recorded a remix of "Maneater" with rapper Lil Wayne, which was featured in a Timbaland's compilation album Remix & Soundtrack Collection. ![]() įurtado has characterized "Maneater" as "a 'couture pop' song", explaining that it is "in your face and very fashionable, stylistic and of-the-moment." In an interview with MTV News, she compared it favorably to eating too much cheesecake: "It's got a crazy loud beat, and the vocals are bitchy and loud. It was life-threatening! Someone almost got first-degree burns". We put it away for a few weeks, until we had the courage to play it again. We felt like it had the devil in it, or something. She feared something about the sound of the music had caused the flames, and for a while was too scared to work on it, Furtado also said "actually we were scared of the beat. Furtado has also confirmed there was a fire in the studio when she was laying down the track, revealing it left her incredibly spooked. Final production of the track was delayed after a speaker caught fire in the studio control room. When making the album, Furtado and Timbaland were influenced by the work of musicians from the 1980s such as the Talking Heads, Blondie, Madonna, the Police, and Eurythmics. Furtado has described the song as an analogy of how she incorporated the "creative energy" of Timbaland and his production crew into Loose. "Maneater" was one of the first songs Furtado and Timbaland worked on in the Hit Factory Criteria recording studios in Miami, Florida. The song was included on the setlist for Furtado's third tour Get Loose Tour. In the United States, the video premiered on Yahoo! Music on 6 September 2006, and was given a "First Look" on MTV's Total Request Live on 8 September. The accompanying music video was filmed by American director Anthony Mandler in Los Angeles. The song became a club hit in North America but was less commercially successful than the lead single " Promiscuous". Outside North America, "Maneater" became one of Furtado's most popular singles, topping the charts in the United Kingdom and peaking within the top ten of the charts across much of Europe and Australia. The song received positive reviews from music critics, with most comparing the song to Madonna and Depeche Mode songs from the 1980s. ![]() The song's musical style and production were inspired by the Hall & Oates song of the same name and other music from the 1980s. It was released to mainstream radio in the United States in July 2006. ![]() The song was written by Furtado, Jim Beanz, and its producers Timbaland, Danja. " Maneater" is a song by Canadian singer Nelly Furtado from her third studio album, Loose (2006). ![]() |
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